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A kinase and a phosphatase: molecular basis of inherited Parkinson’s disease

November 15, 2021 @ 4:00 pm - 5:00 pm

Suzanne Pfeffer, Stanford University School of Medicine
Pathogenic mutations in the Parkinson’s disease-associated LRRK2 kinase increase its activity and lead to phosphorylation of a subset of Rab GTPases that are master regulators of membrane traffic events. Rab phosphorylation flips a switch: Rabs bind new partners, triggering dominant consequences for cell physiology that include blocking primary cilia formation. In this lecture, I will present our latest molecular and cellular analysis of LRRK2 kinase, its corresponding PPM1H phosphatase, and how the coordinated action of these enzymes may lead to specific cell death in the Substantia nigra and eventually, Parkinson’s disease.


November 15, 2021
4:00 pm - 5:00 pm


105 Stanley Hall