Bioengineering Seminar Spring 2022: Nanoparticle delivery to solid tumours

Warren C. W. Chan, Ph.D., Professor and Director of the Institute of Biomedical Engineering, University of Toronto
Abstract: The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing and treating patients. Nanomaterials can transport drugs, contrast agents, immunotherapies, and gene editors to diseased sites. However, less than 1% are delivered to solid tumours, impacting their use and clinical translation for cancer applications. In this presentation, I will discuss the challenge of delivering of medical agents and nanoparticles to solid tumours. The seminar will discuss the impact of nanoparticle design and biology on the in vivo transport process. It will finish with a discussion of strategies to overcome the delivery problem with nano-bio interaction studies, machine learning, and computational analysis.