106 Stanley Hall

Katya Heldwein, Tufts University School of Medicine Herpesviruses are large viruses that infect nearly all vertebrates and some invertebrates and cause lifelong infections in most of the world’s population. During replication, they export their capsids from the nucleus into the cytoplasm by an unusual mechanism termed nuclear egress. Too large to fit through nuclear pores,…

Emily Derbyshire, Duke University

Bil Clemons, Caltech The specific delivery and insertion of integral membrane proteins to the correct lipid bilayer is a critical process for cellular homeostasis. Tail-anchored membrane proteins, defined by a single transmembrane helix at their C-terminus, must be delivered post-translationally. I will describe our recent work to characterize the primary pathway for delivering these proteins…

James Berger, Johns Hopkins University School of Medicine

Sam Sternberg, Columbia University Irving Medical Center Conventional CRISPR–Cas systems maintain genomic integrity by leveraging guide RNAs for the nuclease-dependent degradation of mobile genetic elements, including plasmids and viruses. Here we describe a remarkable inversion of this paradigm, in which bacterial transposons have coopted nuclease-deficient CRISPR–Cas systems to catalyze RNA-guided integration of mobile genetic elements…

Michael Rape, University of California, Berkeley Mitochondria are essential organelles that provide ATP and many metabolic building blocks, but also regulate crucial immune and cell survival pathways. Safeguarding mitochondrial function is therefore essential for development, and dysregulation of these organelles causes severe metabolic or neurodegenerative diseases. We recently discovered the reductive stress response, which detects…

Emily Derbyshire, Duke University Within the liver a single Plasmodium parasite transforms into tens of thousands of blood infective forms to cause malaria. The Derbyshire lab combines chemical biology, biochemistry and genomics to uncover molecular events that drive this transient developmental stage within the liver. Through an integrative approach, we utilize small molecule probes, gene…