A black field with a ctenophore on the left side and a marine sponge on the right side with the word Versus in the middle.

What did the earliest animals look like?

For more than a century, biologists have wondered what the earliest animals were like when they first arose in the ancient oceans over half a billion years ago. Searching among today’s most primitive-looking animals for the earliest branch of the animal tree of life, scientists gradually narrowed the possibilities down to two groups: sponges, which…

Collage of green grass overlaid on the buildings of a biomanufacturing facility.

Tiny Microbes Could Brew Big Benefits for Green Biomanufacturing

A research team led by Lawrence Berkeley National Laboratory (Berkeley Lab) and UC Berkeley has engineered bacteria to produce new-to-nature carbon products that could provide a powerful route to sustainable biochemicals. The advance – which was recently announced in the journal Nature – uses bacteria to combine natural enzymatic reactions with a new-to-nature reaction called the “carbene…

IGI’s ‘Audacious’ New Frontier for CRISPR: Editing Microbiomes for Climate and Health

$70M funding will catalyze a bold new initiative led by Jennifer Doudna and Jill Banfield to apply precision genome editing to microbial communities. The Audacious Project, an initiative housed at TED, encourages the world’s greatest changemakers to dream bigger. A new initiative led by Jennifer Doudna and Jill Banfield at the Innovative Genomics Institute and announced today at…

Biological fluids are made up of hundreds or thousands of different proteins (represented by space filling models above) that evolved to work together efficiently but flexibly

Can synthetic polymers replace the body’s natural proteins?

Most life on Earth is based on polymers of 20 amino acids that have evolved into hundreds of thousands of different, highly specialized proteins. They catalyze reactions, form backbone and muscle and even generate movement. But is all that variety necessary? Could biology work just as well with fewer building blocks and simpler polymers? Ting…

Open Philanthropy awards Conboy lab $3 million to study mechanisms of aging

Open Philanthropy recently announced that QB3-Berkeley faculty affiliate Irina Conboy has been recommended a grant of $3,042,600 over three years to support research led by the Conboy on the mechanisms of aging. In her previous work, Conboy has identified ten new biomarkers and a set of pathways that may potentially be involved in the repression of…

An illustration of an hourglass featuring parts of a phage.

How to Edit the Genes of Nature’s Master Manipulators

CRISPR, the Nobel Prize-winning gene editing technology, is poised to have a profound impact on the fields of microbiology and medicine yet again. A team led by CRISPR pioneer Jennifer Doudna and her longtime collaborator Jill Banfield has developed a clever tool to edit the genomes of bacteria-infecting viruses called bacteriophages using a rare form…

Alien bits of DNA that inhabit single-celled microorganisms known as archaea, shown here in a scanning-electron microscope image, appear to assimilate the genes of their hosts, much like the Borg in Star Trek. These large lengths of DNA may be augmenting archaea’s ability to remove methane from soil and thus could play a role in reducing this potent greenhouse gas.

Like the Borg of Star Trek, these ‘aliens’ assimilate DNA from other microbes

Only a meter or two below our feet dwells a wealth of microbes whose riches remain largely unexplored. It’s a realm where bacteria, bacteria-like organisms called archaea and fungi mingle with viruses and other non-living bits of DNA or DNA — all living with, in or on one another. In that alien world, researchers have…

Two flasks of green algae sit in a spinner

UC Berkeley, Berkeley Lab researchers receive $11.6 million in Department of Energy funding

Teams led by researchers from UC Berkeley, the California Institute for Quantitative Biosciences (QB3), and Berkeley Lab have received a combined $11.6 million from the U.S. Department of Energy (DOE) to develop biofuel and bioproducts from a photosynthetic micro-alga. The funding is part of $178 million in DOE awards granted to 37 projects that will develop new…