A detailed look at tail-anchored membrane protein targeting – from opisthokonts to protists to plants

Bil Clemons, Caltech
The specific delivery and insertion of integral membrane proteins to the correct lipid bilayer is a critical process for cellular homeostasis. Tail-anchored membrane proteins, defined by a single transmembrane helix at their C-terminus, must be delivered post-translationally. I will describe our recent work to characterize the primary pathway for delivering these proteins to the ER and expand on the broader conservation of this process across eukaryotes.