QB3 Mass Spectrometry’s Recent Papers
Heel-Juen, S. V.; Plangger, R.; Chen, C. J.; Miller, Z. M.; Juen, F.; Kreutz, C.; Williams, E. R. “Uncovering the structural landscape of heat-induced riboswitch RNA unfolding using native variable-temperature ESI ion mobility mass spectrometry and 1H NMR.” JACS Au 2026, 6, 3703-3712.
MacRae, N. S.; Dong, K. C.; Harimoto, H.; Martin, A. “Identification of novel ubiquitin receptors on the 26S proteasome by photo-crosslinking mass spectrometry.” J. Biol. Chem. 2026, 302, 111481.
Winegar, P. H.; Hudson, G. A.; Benedict, R. P.; Sy, C. Z.; Han, T. Y.; FitzGerald, D. M.; Mahajan, R. S.; Gravel, P. J.; Roberts, J. B.; Lanclos, N.; Huang, M.; Iavarone, A. T.; Keasling, J. D. “Biocatalytic C3 β-O-glycosylation of triterpenes and sterols to synthesize natural and unnatural saponins.” J. Am. Chem. Soc. 2026, 148, 29124-29137.
Steele, R. T.; Domack, J.; Sarpong, R. “Formal nitrogen-to-carbon replacement in isoindolines to form indenes via N-alkyl tetrahydroisoquinolines.” Chem. Sci. 2026, 17, 14801-14808.
Roan, J. J. W.; Siddiqi, Z.; Abel, B. A. “Molecular weight-controlled cationic polymerization of tetrahydrofuran using a squaramidinium hydrogen-bond donor catalyst.” J. Am. Chem. Soc. 2026, 148, 4397-4405.
Witus, S. R.; Kober, M. M.; Roh, H.; Yang, Z.; Choueiry, F.; Ghate, A. S.; Titov, D. V.; Rapé, M. “Metabolite glues as a means of purine sensing and chemotherapeutic response.” Nature 2026, 655, 1300-1308.
Modi, A.; Toriki, E. S.; Stieger, C. E.; Lau, E. A.; Song, C.; Chew, A.; Tsao, A.; Nishikawa, K.; McKenna, J.; Nomura, D. K. “An optimized RNF126-targeting covalent handle for molecular glue degraders.” Bioorg. Med. Chem. Lett. 2026, 140, 130743.
Adler, S. A.; Nayak, D. D. “Component A2 is a redox-sensitive archaeal ATPase activated by methyl-coenzyme M reductase.” Curr. Biol. 2026, 36, 3595-3607.e7.
Tuck, O. T.; Hu, J. J.; Lopez, S. C.; Adler, B. A.; O’Brien, C. E.; Hsieh, K.; Meredith, C.; Loi, K. J.; Yoon, P. H.; Doherty, E. E.; Lahiri, A.; Doudna, J. A. “Recurrent acquisition of nuclease-protease pairs in antiviral immunity.” Science 2026, 391, 195-201.
Wang, Z.; Qie, B.; Tang, W.; Jiang, J.; Liu, F.; Jacobse, P. H.; Lu, J.; Li, X.; Louie, S. G.; Fischer, F. R.; Crommie, M. F.; “Pseudo–Jahn–Teller distortion in a one-dimensional π‑conjugated polymer.” J. Am. Chem. Soc. 2026, 148, 7723-7730.
Xie, Y.; Wang, Y.; Ma, S.; Xi, Y.; Hartwig, J. F.; “Direct observation of selective migratory insertion of unactivated terminal alkenes into Ir–N bonds.” J. Am. Chem. Soc. 2026, 148, 14296-14308.
Lee, I. J.; Li, Q.; Raskar, T.; Pellegrino, J.; Ecker, A. K.; Howard, S. Y.; Fraser, J. S.; Seiple, I. B. “Structure-based design and synthesis of group A streptogramins that bind to the nascent peptide exit tunnel of the ribosome.” Eur. J. Med. Chem. 2026, 316, 118947.
Manske, J. L.; Jeon, Y.; Kim, S.; Hurlburt, A. S.; Khan, H.; Baik, M.-H.; Hartwig, J. F.; “Observed versus predicted reactivity, selectivity, and mechanism of iridium catalysts with pyridyl carbene ligands for the borylation of C–H bonds.” J. Am. Chem. Soc. 2026, 148, 4051-4061.
Moseley, J. L.; Merchant, S. S. “Genetically pliable green algae for bioproduction of modified fatty acids, nutritional therapeutic oils, and biopharmaceuticals.” Curr. Opin. Biotechnol. 2026, 97, 103421.
La, C.; Ryabukhin, S. V.; Volochnyuk, D. M.; Hartwig, J. F. “Mapping the undirected borylation of C(sp3)-H bonds in strained rings.” J. Am. Chem. Soc. 2026, 148, 1703-1716.
Delgado, A. P.; Daugherty, M. C.; Tang, W.; Louie, S. G.; Fischer, F. R.; “Ferromagnetic insulator to metal transition in noncentrosymmetric graphene nanoribbons.” J. Am. Chem. Soc. 2026, 148, 16099-16106.
Siddiqi, Z.; Abel, B. A. “Chemically circular poly(orthoester) elastomers synthesized by halogen-bond donor catalyzed cationic ring-opening polymerization.” Angew. Chem. 2026, 138, e1570414.
Mirzaei, S.; Gao, M.-Y.; Alawadhi, A. H.; Nguyen, H. L.; Zhou, Z.; Singh, V.; Ahn, D. D.; Proserpio, D. M.; O’Keeffe, M.; Yaghi, O. M. “Twelve-connected nanographene-based metal-organic frameworks.” Chem 2026, 12, 102830.
Yin, K.; Landera, A.; Lee, N.; Iavarone, A. T.; Kosina, S. M.; Young, T. D.; Deng, K.; Baerwald, J.; Chen, Y.; Gin, J. W.; Benedict, R.; Chiu, Y.; Ukabiala, E.; Kamruzzaman, M.; Poorey, K.; Northen, T. R.; Petzold, C. J.; George, A.; Cruz-Morales, P.; Dan, Q.; Keasling, J. D. “Polyketide synthase-based controlled synthesis of polycyclopropanated fuel molecules.” Nat. Commun. 2026, 17, 6904.
Aronson, H. S.; Weaver Jr., M. E.; Hu, R.; Lanclos, V. C.; Rapp, J. D.; Iavarone, A. T.; Carlson, H. K.; Coates, J. D. “Lithosyntrophy: Obligate syntrophy in a phosphite-oxidizing, methanogenic culture.” Proc. Natl. Acad. Sci. U.S.A. 2026, 123, e2523765123.
Remick, B. C.; Mao, J. Q.; Manford, A. G.; Gutierrez-Jensen, A. D.; Wagner, A.; Rape, M.; McFadden, G.; Rahman, M. M.; Gaidt, M. M.; Vance, R. E. “Poxvirus attack of antiviral defense pathways unleashes an effector-triggered NF-κB response.” Science 2026, 391, eadw4937.
Kennedy, D. R.; Lemière, J.; Amine, A. A.; Martin, E. W.; Tan, C.; Simental, E.; Braxton, J.; Maxwell, R. A.; Al-Sady, B. “Phosphorylation of HP1/Swi6 relieves competition with Suv39/Clr4 on nucleosomes and enables H3K9 trimethyl spreading.” Nucleic Acids Res. 2025, 53, gkaf1244.
Ng, H. Y.; Whelpley, D. H.; Adly, A. N.; Maxwell, R. A.; Morgan, D. O. “Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing.” Nat. Commun. 2025, 16, 4281.
Lou, S.; Tihagam, R. D.; Wasko, U. N.; Equbal, Z.; Venkatesan, S.; Braczyk, K.; Przanowski, P.; Koo, B. I.; Saltani, I.; Singh, A. T.; Likhite, S.; Powers, S.; Souza, G. M. P. R.; Maxwell, R. A.; Yu, J.; Zhu, L. J.; Beenhakker, M.; Abbott, S. B. G.; Lu, Z.; Green, M. R.; Meyer, K. C.; Tushir-Singh, J.; Bhatnagar, S. “Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype.” Nat. Commun. 2025, 16, 6169.
Doherty, E. E.; Nomburg, J.; Adler, B. A.; Lopez, S.; Hsieh, K.; Price, N.; Blount, N.; Doudna, J. A. “Divergent viral phosphodiesterases for immune signaling evasion.” Cell Host & Microbe 2025, 33, 2043-2051.e6.
Tuck, O. T.; Hu, J. J.; Lopez, S. C.; Adler, B. A.; O’Brien, C. E.; Hsieh, K.; Meredith, C.; Loi, K. J.; Yoon, P. H.; Doherty, E. E.; Lahiri, A.; Doudna, J. A. “Recurrent acquisition of nuclease-protease pairs in antiviral immunity.” Science 2025, 0, eaea8769.
Dadich, C. M.; Fischer, F. R. “Bidirectional Suzuki catalyst transfer polymerization of poly(p-phenylene).” Macromolecules 2025, 58, 13, 6563-6569.
Lu, D.; Kwon, H.; Held, L. I.; McClain, K. R.; Ngo, D. X.; Ye, M.; Tsai, H.; Vincent, A. H.; Harris, T. D.; Long, J. R. “Dy(BC4Ph5)(C5iPr5): A heteroleptic sandwich complex with strong axiality giving rise to magnetic blocking at 65 K.” Inorg. Chem. 2025, 64, 45, 22376-22383.
Doherty, E. E.; Adler, B. A.; Yoon, P. H.; Hsieh, K.; Loi, K.; Armbruster, E. G.; Lahiri, A.; Bolling, C. S.; Wilcox, X. E.; Akkati, A.; Iavarone, A. T.; Pogliano, J.; Doudna, J. A. “A miniature CRISPR-Cas10 enzyme confers immunity by inhibitory signalling.” Nature 2025, 647, 997-1004.
Voke, E.; Arral, M. L.; Squire, H. J.; Lin, T.-J.; Zheng, L.; Coreas, R.; Lui, A.; Iavarone, A. T.; Pinals, R. L.; Whitehead, K. A.; Landry, M. P. “Protein corona formed on lipid nanoparticles compromises delivery efficiency of mRNA cargo.” Nat. Commun. 2025, 16, 8699.
Dubey, P.; Somani, A.; Lin, J.; Iavarone, A. T.; Klinman, J. P. “Dynamically interacting protein networks provide a mechanism to overcome the enormous intrinsic barrier to orotidine 5′-monophosphate decarboxylation.” ACS Cent. Sci. 2025, 11, 1377-1390.
Cook, A. S. I.; Chen, M.; Nguyen, T. N.; Cabezudo, A. C.; Khuu, G.; Rao, S.; Garcia, S. N.; Yang, M.; Iavarone, A. T.; Ren, X.; Lazarou, M.; Hummer, G.; Hurley, J. H. “Structural pathway for PI3-kinase regulation by VPS15 in autophagy.” Science 2025, 388, eadl3787.
Craescu, C. V.; Stahl, S.; Correia, T. L. F.; Bierschenk, S. M.; Settineri, N. S.; Bergman, R. G.; Raymond, K. N.; Toste, F. D. “Tuning the conformations of an M4L4 cage and their impact on catalysis.” J. Am. Chem. Soc. 2025, 147, 36, 32600-32609.
Andrei, V.; Roh, I.; Lin, J.-A.; Lee, J.; Shan, Y.; Lin, C.-K.; Shelton, S.; Reisner, E.; Yang, P. “Perovskite-driven solar C2 hydrocarbon synthesis from CO2.” Nat. Catal. 2025, 8, 137-146.
Pudner, G. L.; Dessain, S.; Wu, E. K.; Sarpong, R. “Synthesis of benzo-fused cycloheptanones from cyclobutanol derivatives by a C–C cleavage/cross-coupling/enolate arylation sequence.” Synthesis 2025, 57, 1982-1996.
Spieß, P.; Peloewetse, A. S.; Profyllidou, A.; Kraus, S. L.; Santarelli, N.; Fukuyama, T.; Kohrt, J. T.; Blakemore, C. A.; Na, C. G.; Sarpong, R.; Bagley, S. W. “Annulative skeletal diversification of pyrimidines to expanded heteroaromatic space.” J. Am. Chem. Soc. 2025, 147, 45841-45848.
Yu, K.; Gorou, A.; Huang, D.; Maimone, T. J. “Short, enantioselective total synthesis of (+)-ineleganolide.” J. Am. Chem. Soc. 2025, 147, 44727-44732.
Amber, C.; Petitjean, T. M.; Sirvinskaite, G.; Steele, R. T.; Sprague, B.; Domack, J.; Small, D. W.; Sarpong, R. “Two-step constitutional isomerization of saturated cyclic amines using borane catalysis.” JACS Au 2025, 5, 851-857.
Akiyama, S.; Ople, R. S.; Kremsmair, A.; Ramos-Gonzalez, N.; Nedungadan, T.; Kennedy, B. J.; Appourchaux, K.; Eans, S. O.; Tsai, B. A.; Kraml, C.; Huang, X.; McLaughlin, J. P.; Majumdar, S.; Sarpong, R. “Total synthesis and biological activity of “carbamorphine”: O-to-CH2 replacement in the E-ring of the morphine core structure.” Proc. Natl. Acad. Sci. U.S.A. 2025, 122, e2425438122.
Chen, C. J.; Avadhani, V. S.; Williams, E. R. “Electronic excitation and high-energy reactions originate from anionic microdroplets formed by electrospray or pneumatic nebulization.” Angew. Chem. Int. Ed. 2025, 64, e202424662.
Liu, F.; Yan, Y.; Tang, W.; Qie, B.; Chen, J.; Wang, Z.; Louie, S. G.; Fischer, F. R. “Orbital engineering band degeneracy in a dual-square carbon-oxide framework.” ACS Nano 2025, 19, 15139-15147.
Bartholomew, G. L.; Kim, S. F.; Oyamada, Y.; Sbordone, F.; Carroll, J. A.; Jurczyk, J. E.; Yeung, C. S.; Barner-Kowollik, C.; Sarpong, R. “Phototransposition of indazoles to benzimidazoles: Tautomer-dependent reactivity, wavelength dependence, and continuous flow studies.” Angew. Chem. Int. Ed. 2025, 64, e202423803.
Kim, S. F.; Liles, J. P.; Lux, M. C.; Park, H.; Jurczyk, J.; Soda, Y.; Yeung, C. S.; Sigman, M. S.; Sarpong, R. “Interrogation of enantioselectivity in the photomediated ring contractions of saturated heterocycles.” J. Am. Chem. Soc. 2025, 147, 1851-1866.
Chen, C. J.; Williams, E. R. “An alternative explanation for ions put forth as evidence for abundant hydroxyl radicals formed due to the intrinsic electric field at the surface of water droplets.” Anal. Chem. 2025, 97, 17687-17695.
Chen, C. J.; Williams, E. R. “A source of the mysterious m/z 36 ions identified: Implications for the stability of water and unusual chemistry in microdroplets.” ACS Cent. Sci. 2025, 11, 622-628.
Jordan, J. S.; Chen, C. J.; Lee, K. J.; Williams, E. R. “Temperature induced unfolding and compaction of cytochrome c in the same aqueous solutions.” J. Am. Chem. Soc. 2025, 147, 3412-3420.
Woods, J. J.; Rigby, A.; Wacker, J. N.; Arino, T.; Alvarenga Vasquez, J. V.; Cosby, A.; Martin, K. E.; Abergel, R. J. “Synthesis and evaluation of a bifunctional chelator for thorium-227 targeted radiotherapy.” J. Med. Chem. 2025, 68, 1682-1692.